Latex sensitivity and allergy

Related theory

Latex is a natural rubber composed of proteins and added chemicals. Its durable, flexible properties give it a high degree of protection from many micro‐organisms, which makes it an ideal fibre to use for many healthcare products. It currently provides the best protection against infection in the healthcare field. It is found in the following products:
  • gloves
  • airways
  • intravenous tubing
  • stethoscopes
  • catheters
  • wound drains
  • dressings and bandages (HSE [81]).
Some of the proteins in the natural rubber latex can cause sensitivity and allergic reactions, and the incidence of latex hypersensitivity seems to be increasing (Wu et al. [236]). Powdered gloves can create the greatest risk as proteins leak into the powder, which can become airborne when gloves are removed, and inhaling the powder may lead to respiratory sensitization. The amount of latex exposure needed to produce sensitization is unknown. Sensitivity can be described as the development of an immunological memory for specific latex proteins, which can be asymptomatic. A substance that causes sensitization is one that is capable of causing an allergic reaction in certain people. Allergy is the visible manifestation of the sensitivity (e.g. hives, rhinitis, conjunctivitis or anaphylaxis), which can be serious and potentially life threatening (Table 16.8) (Hauk [74], HSE [81]).
Table 16.8  Allergic reactions
Reactionc16-note-0001DescriptionSymptoms
IrritationIrritant contact dermatitis, a non‐allergenic reaction caused by soaps, gloves, glove powder and hand creams
Dry, crusty and itchy skin
Rashes and inflammation
Type I reaction: immediate hypersensitivity – occurs within minutes and can fade rapidly after removal of the latexImmediate hypersensitivity, sometimes called immunoglobulin E response; caused by exposure to proteins in latex on glove surface and/or bound to powder
Most severe reaction
Wheal and flare response
Irritant and allergic contact
Dermatitis
Facial swelling
Rhinitis
Urticaria
Respiratory distress and asthma
Rarely, anaphylactic shock
Type IV reaction: delayed hypersensitivity – usually occurring within 6–48 hours of contactSometimes known as ‘allergic contact dermatitis’, caused by exposure to chemicals used in latex manufacturingRed, raised, palpable area with bumps, sores and cracks
* Type II and type III reactions are not relevant to latex.
Source: Adapted from AORN ([22]), HSE ([81]).
Once sensitization has taken place, further exposure will cause symptoms to recur, and increasing exposure to latex proteins increases the risk of developing allergic symptoms (HSE [81]). Therefore, sensitivities and allergies should be treated in the same way (Hauk [74]). Routes of exposure include:
  • direct external contact (i.e. with gloves or other latex products)
  • airborne exposure
  • direct contact with the mucous membranes
  • internal patient exposure from healthcare provider use of natural rubber latex gloves during surgical procedures
  • internally placed devices (e.g. wound drains) (AORN [22]).
Latex allergies are classified as irritant contact dermatitis, type I and type IV reactions (see Table 16.8).

Clinical governance

Healthcare providers have an ethical responsibility to prevent latex sensitization; because there is no cure, protection must be paramount. Employers should have a latex allergy policy and procedure, which should provide information and instruction on measures to identify patients at risk, patient education, interventions to reduce undue latex exposure, recognizing symptoms of sensitization and the action to be taken if a sensitization is suspected (HSE [81]).
Assessment and monitoring for symptoms of latex allergy in both conscious and unconscious patients are required at all stages of perioperative care. The assessment should cover the following known risk factors for latex allergy:
  • history of multiple surgeries beginning at an early age (e.g. spina bifida or urinary malformation)
  • history of hayfever or asthma
  • history of an allergic reaction to latex: for example, a history suggestive of reactivity to latex may be gained by anecdotal accounts of swelling or itching of the lips when blowing up balloons or following dental examinations, or swelling and itching of the hands when using household gloves
  • history of an allergic reaction during an operation
  • past experience of itchy skin, skin rash or redness when in contact with rubber products
  • past skin irritation from an examination by a doctor or dentist wearing rubber gloves
  • past sneezing, wheezing or chest tightness when exposed to rubber (AORN [19]).
If a suspected or confirmed latex sensitivity or allergy is found, this information must be documented in the patient's medical notes and communicated to all members of the healthcare team and departments that the patient may visit, including theatre, recovery, pathology and radiology (Liberatore [102]). Box 16.9 outlines the pre‐operative actions to be taken when a patient has a potential or confirmed latex allergy. The anaesthetist will need to be informed so that decisions can be made regarding potential allergy prophylaxis pre‐operatively. A latex‐safe environment is recommended – one where every reasonable effort has been made to prevent high‐allergen and airborne latex sources from coming into direct contact with affected individuals. Latex‐free alternative items should be collected and stored in a quick‐access location for ease of access and identification. At present, best practice dictates that patients with a suspected or confirmed latex allergy be scheduled first on the morning list because it is assumed that the inactivity in the room during the previous evening hours causes the content of latex‐coated powder in the ambient air to be lowest in the morning (AORN [22], Hauk [74]). Further guidance may be sought online from the Association of periOperative Registered Nurses (www.aorn.org).
There is a voluntary scheme in place for reporting cases of latex sensitization, both of staff and patients, to the Medical Devices Agency, which is an executive agency of the Department of Health (HSE [81]).
Box 16.9
Pre‐operative actions to be taken when patients have a potential or confirmed latex allergy
  • Notify operating theatre of potential or confirmed latex allergy 24–48 hours (or as soon as possible) before the scheduled procedure.
  • Identify the patient's risk factors for latex allergy and communicate them to the healthcare team.
  • Schedule the procedure as the first case of the day if the facility is not latex safe.
  • Plan for a latex‐safe environment of care.
  • The theatre must be cleaned with latex‐free gloves and equipment.
  • All latex products must be removed or covered with plastics so that the rubber elements are not exposed.
  • All healthcare staff in direct contact with the patient must wear vinyl gloves during procedures and in the vicinity of the patient.
  • Use latex‐free replacements for all latex‐containing items used by surgeons and anaesthetists.
  • A latex‐free contents box or trolley (containing stock of all latex‐free products that will be required during surgery and anaesthetic) should be ready in every theatre department and recovery room. There should be a list of all latex‐free equipment (including each item's manufacturer) available in the box or trolley.
  • Notify the surgeon if no alternative product is available.
  • Notify the anaesthetist if a latex‐containing product must be used and develop a plan of emergency care if necessary.
  • Where a type I (immediate hypersensitivity reaction; see Table 16.8) allergy is suspected, suitable clinical management procedures must be ready for use in the event of the patient having a hypersensitivity reaction.
Source: Adapted from AORN ([22]).