23.8 Cytotoxic therapy: intraventricular administration of cytotoxic drugs via an intraventricular access device (Ommaya reservoir)

Essential equipment

  • 25 G winged infusion devices or small non‐coring needle
  • Sterile dressing pack
  • Cleaning solution
  • Pre‐prepared chemotherapy
  • Three‐way tap

Pre‐procedure

ActionRationale

  1. 1.
    Explain and discuss the procedure with the patient.
    To ensure that the patient understands the procedure and gives their valid consent (Griffith et al. [91], E; NMC [177], C).
  2. 2.
    Consult the patient's prescription sheet, and ascertain the following:
    1. Drug.
    2. Dose.
    3. Date and time of administration.
    4. Route and method of administration.
    5. Diluent as appropriate.
    6. Validity of prescription.
    7. Signature of doctor.
    8. Allergy status.
    To ensure that the patient is given the correct drug in the prescribed dose using the appropriate diluent and by the correct route (NPSA [167], C).
  3. 3.
    Position the patient comfortably.
    To gain access to the site. E
  4. 4.
    Apply apron and necessary personal protective equipment, for example gloves, goggles.
    To protect the practitioner from splashes and spills (HSE [104], C; Polovich [192], E; RCN [201], C).
  5. 5.
    Wash hands with antibacterial soap.
    To prevent contamination (Fraise and Bradley [77], E).
  6. 6.
    Open sterile pack and pour antiseptic liquid into gallipot.
    To prepare the area. E
  7. 7.
    Open intrathecal chemotherapy drugs by cutting plastic pack and place on sterile field.
    To gain access to chemotherapy. E
  8. 8.
    Open non‐coring winged infusion device and connect a three‐way tap to the tubing.
    To prepare the equipment. E
  9. 9.
    Clean hands with alcohol gel.
    To prevent contamination (Fraise and Bradley [77], E).

Procedure

  1. 10.
    Locate the reservoir by slightly depressing the dome several times. There should be free flow of CSF from the ventricle into the dome.
    To ascertain where the reservoir is and that it is functional (RCN [201], C).
  2. 11.
    Wash hands with antibacterial handwash and put on sterile gloves.
    To prevent contamination (Fraise and Bradley [77], E).
  3. 12.
    Prepare the skin by cleaning the site.
    To minimize risk of infection (Fraise and Bradley [77], E).
  4. 13.
    Using the 25 G needle, access the reservoir and remove a small amount of CSF equal to the amount of drug to be instilled.
    To check free flow of CSF and patency of reservoir (RCN [201], C).
  5. 14.
    Connect syringe containing chemotherapy to three‐way tap and inject slowly. No resistance should be felt.
    To maintain a closed system and administer medication (RCN [201], C).
  6. 15.
    Compress and release the dome after all medication is given.
    To facilitate medication administration and dispense the drug (RCN [201], C).
  7. 16.
    The reservoir can now be flushed with the CSF removed at the start of the procedure. Do not flush with 0.9% sodium chloride or heparin.
    Flushing is not required as CSF flows freely through the device (RCN [201], C; E).
  8. 17.
    Remove the needle and apply pressure with gauze.
    To prevent leakage of CSF or chemotherapy. E
  9. 18.
    Dispose of sharps and syringe in a purple‐lidded sharps container.
    To maintain a safe environment. E
  10. 19.
    Once CSF stops leaking, apply a small gauze dressing and tape.
    To minimize risk of infection (Fraise and Bradley [77], E).

Post‐procedure

  1. 20.
    Assist patient in repositioning if required.
    To maintain comfort. E
  2. 21.
    Dispose of equipment in appropriate waste bags.
    To maintain a safe environment. E
  3. 22.
    Wash and dry hands.
    To minimize risk of contamination (Fraise and Bradley [77], E).
  4. 23.
    Document chemotherapy administration on the prescription chart.
    To maintain records and for continuity of care (NMC [178], C).
  5. 24.
    Monitor the patient for any side‐effects of the drugs and check reservoir site for any leaks.
    To recognize complications early and report to medical staff (RCN [201], C).