Chapter 23: Administration of systemic anticancer therapies
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Evidence‐based approaches
Rationale
Indications
- Intravesical instillation has been shown to be effective in the treatment of small, multiple, superficial, well‐differentiated, non‐invasive papillomatous carcinomas as high drug concentrations can be achieved using this route because there is limited penetration of the drug into normal and malignant tissue.
- This method is only of benefit when treating small and superficial disease (Scurr [227]).
- It minimizes recurrence in patients with a history of multiple tumours known to readily seed locally (Stanley [239]).
- It also reduces cytotoxic exposure to patients and their carers because excretion of the drug is quicker than when administered systemically (Washburn [264]).
