It is essential that the allergy status of the patient is known and recorded in the patient's notes as failure to do so can have catastrophic results (DH [44]). All healthcare professionals have a responsibility to ensure that the allergy status of the patient has been assessed and recorded correctly, which should happen at every intervention. It is known that the use of taxanes is associated with a high risk of hypersensitivity and local policies should be adopted to manage any adverse drug reaction. The risk of allergic reactions can be reduced by administering hydrocortisone and chlorphenamine prior to administration of SACT and many organizations have a protocol to manage such reactions. Symptoms of a reaction are flushing, dizziness, restlessness, breathlessness, chest pain, tachycardia, hypertension, nausea or abdominal pain. Such reactions will normally resolve with the administration of antihistamines and corticosteroids as described above. Reactions are often classed by a grading system of severity and should always be documented in the patient's clinical notes. To manage severe or reoccurring sensitivities that do not respond to hydrocortisone and chlorphenamine, a desensitization programme that involves delivering the total drug in smaller infusion doses over a longer period of time can help.