Anatomy and physiology

In the days and hours leading up to an expected death, the following are common (Fürst [8], NICE [8]):
  • a weaker pulse (but regular unless previously arrhythmic)
  • a gradual drop in blood pressure (though at this stage it should not be routinely taken)
  • shallower, slower breathing which varies in depth, often in a Cheyne–Stokes pattern
  • a decreasing level of consciousness leading eventually to coma, except in those few patients who remain awake until a few minutes before they die
  • cooling and clamminess of the skin from the periphery towards the main trunk
  • cyanosis of the skin on the extremities and around the mouth
  • eventual loss of all signs of cardiorespiratory function and the corneal reflex – death is said to occur at this point.